A LITTLE HISTORY

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RECRUITMENT

RESOURCES

Patient Recruitment Resources (Among Others)

History

The concepts behind clinical trials are ancient. The Book of Daniel chapter 1, verses 12 through 15, for instance, describes a planned experiment with both baseline and follow-up observations of two groups who either partook of, or did not partake of, “the King’s meat” over a trial period of ten days. Persian physician Avicenna, in The Canon of Medicine (1025) gave similar advice for determining the efficacy of medical drugs and substances.

Development

The first proper clinical trial was conducted by the physician James Lind. The disease scurvy, now known to be caused by a Vitamin C deficiency, would often have terrible effects on the welfare of the crew of long distance voyages. In 1740, the catastrophic result of Anson’s circumnavigation attracted much attention in Europe; out of 1900 men, 1400 had died, most of them allegedly from having contracted scurvy. 

Consulting Sources/References

  • Clinical Trials Gov.

  • National Institute of Health (NIH)

  • Medline Plus. U.S. National Library of Medicine

  • U.S. Food and Drug Administration (FDA)

  • Bsc Human Biosciences – Plymouth University

  • Bill and Melinda Gates Foundation. Retrieved January 2014.

  • Acceptable Risk in Biomedical Research. Dr. Sigmund Simonsen. Norwegian University of Science and Technology NTNU.

Notebook

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